Salusin-β in rostral ventrolateral medulla increases sympathetic outflow and blood pressure via superoxide anions in hypertensive rats

Within this article, the laboratory is trying to find out the role of salsulin-b within the RVLM in sympathetic nerve activity. They used Sprague dawley rats with induced renovascular hypertension. The two test groups were 2K1C and sham. The 2K1C rats had a clip on the right renal artery while the sham rats did not.  Salusin-b was injected into the RVLM and throughout the course of 4 weeks, an increase in sympathetic nerve activity was found in 2K1C rats and not in sham rats (the two rat models utilized). This finding shows significance due to the role it can play in understanding possible RVLM regulation of sympathetic nerve activity and ultimately blood pressure.

-Hashbrown