Verberne AJ, Sartor DM.
Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E802-7.
I came across this paper by accident, but it is dealing with
presympathetic RVLM neurons, so I read it. It’s not about the ones we normally
study, but it very much could be about some of the neurons I’ve been finding in
my recordings. In this paper they looked at spinally projecting unmyelinated
RVLM neurons that were NOT barosensitive, but were sensitive to changes in
glucose concentration. These neurons increased their activity during
2-deoxyglucose (2-DG) induced neuroglocoprivation, presumably to drive
increased epinephrine release from the adrenal glands in order to compensate
for hypoglycemia. When they injected bicuculline in to the region of the RVLM
where these glucosensitive were found, not only did they see the expected
increase in arterial pressure, but they also saw that the rat’s blood glucose
levels went up. This did not occur in rats that had undergone bilateral
adrenalectomy. Interestingly, the barosensitive neurons they found were either
not affected by 2-DG, or were slightly inhibited – so this is another
subpopulation of neurons in the same region, which may support the idea of
differential control that we’ve been looking at. -DH
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