Tetsuya Kawabe, Kazumi Kawabe, and Hreday N. Sapru.Am J Physiol Heart Circ Physiol 306: H438–H449, 2014. First published November 27, 2013; doi:10.1152/ajpheart.00628. 2013. This study investigated whether ang 1-12 is leading to increased neuronal activity through AT1 Receptors in the cvlm. In Wistar rats, they recorded GSNA, BP, and HR and used microinjection technique. They found that microinjections of ang 1-12 into cvlm lead to decreases in BP, HR and GSNA. Ang 1-12 mediates it response through AT1R. The activation of AT1R leads to the release of GABA from the terminals of CVLM neurons and acts on GABA receptors in the RVLM in order to cause sympathoinhibition. In conclusion, Ang 1-12 maybe playing a role in the activation of neurons in the CVLM. I wonder if the level of Ang 1-12 is changing in response exercise…MD
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