Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats

Exercise Training Causes Sympathoinhibition Through Antioxidant

Effect in the Rostral Ventrolateral Medulla of Hypertensive Rats


Takuya Kishi,Yoshitaka Hirooka,2 Masato Katsuki,1 Kiyohiro Ogawa,1 Keisuke Shinohara,Kengo Isegawa,Kenji Sunagawa1

Background: Exercise training (extr) reduces SNS activity in heart failure (hf). Exercise also enhances baroreflex sensitivy in hf. In the RVLM oxidativae stress enhances SNS activity via AT1R activiation. Other studies have shown that NO in RVLM leads to deceased SNS activity. It may be possible that an imbalance of NO and oxidative stress could cause cardiovascular diseases.

Aim: This study investigated the effects of exercise training on SNS activity and oxidative stress in the RVLM of hypertensive rats.

Methods: They measured MAP, HR, and urinary NE excretion as a measurement of SNS activity, bbarosensitivity, and oxidative stress in the RVLM of hypertensive and norm rats with exercisse training. They used tempol in the RVLM to inhibit oxidative stress. Also they injected ang II in the RVLM of hypertensive and Norm rats with exercise training.

results/findings: first they found that extr caused smpathoinhibition and improved the impaired baroreflex sensitivity in the SHRSP. They also found that extr reduced oxidative stress in RVLM of SHRSP. finally they demostrated that the depressor response caused by tempol and angII pressor responses in RVLM caused smaller responses with extr compared to control.

Conclusion: Extr causes sympathoinhibition and improves impaired baroreflex sensitivity via antioxidant in the RVLM through blocked AT1R in RVLM.