Within this article, Duchenne muscular dystrophy (DMD) is
discussed in its affect towards heart failure. It is explained how dystrophin,
a protein that connects the cytoskeleton of a muscle fiber to the surrounding
extracellular matrix through the cell membrane, deficiency can cause DMD. It
was seen that a deficiency in dystrophin can cause less stability in the myocyte
membranes and lead to stretch mediated calcium overload. In attempt to learn more
about counteracting this, the lab had one control group of rats and monitored
the ability of the myocytes to stretch and relax. The control group was
compared to a group of dystrophin deficient mice (mdx). The lab would treat mdx
rats with poloxamer 188 (p188) and it showed to significantly reduce tension
compared to mdx rats not treated with it.
Hashbrown
No comments:
Post a Comment