Cardiovascular effects of angiotensin II and angiotensin-(1–7) at the RVLM of trained normotensive rats

Lenice K. Becker, Robson A.S. Santos, Maria José Campagnole-Santos Brain Research Volume 1040, Issues 1–2, 8 April 2005, Pages 121–128 http://dx.doi.org/10.1016/j.brainres.2005.01.085 They used wistar rats and microinjected ang II, ang 1-7, saline,for 5 days a week . They found that the trained rats had a greater pressor response to ang II whe compared to sedentary rats. Ang 1-7 responses were greater pressor responses in seds. then they gave an antagonist Lorstan and saw a greater depressor responses in sedentary than compared to trained. When they gave the A779 they saw a greater depressor responses in sedentary compared to trained animals. The differential effects produced in response to ang peptides in trained rats could be due to an increase in AT1 and decreased in MAS receptor expression on excitatory neurons.-MD