The purpose of this study was to determine the physiological effects of angiotensin (1-12) in the caudal ventrolateral medulla. They used microinjection technique in order to determine the role that ang(1-12) is playing in control of MAP and GSNA. They found that ang 1-12 caused decreases in MAP, HR, and GSNA. In response to ACE inhibitor injection in the CVLM, the ang 1-12 response was blocked. Also that GABA receptor blockade in the RVLM, lead to blunted ang 1-12 responses. The also looked the effects of AT1R and AT2R blockade in the CVLM and they found that blockade of AT1R blocked the response to ang 1-12. The AT2R did not affect the response to ang 1-12.
Conclusion: Ang 1-12 may be broken down into Ang II and ang 1-7 and these two neurotransmitters are mediating the decrease in MAP, HR, and GSNA by binding to AT1Rs in the CVLM. Then finally the GABA receptors in the RVLM are also playing role in mediating the the physiological response to Ang 1-12.
-MD
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