Cardiovascular Effects Produced By Activation of GABA Receptors In The Rostral Ventrolateral Medulla of Conscious Rats

The major inhibitory neurotransmitter is GABA .As we already know anesthesia can potentiate the effects of GABA. In this article they looked at the role of GABA on GABA _A and GABA _B receptors in conscious animals. They used Wistar rats. They only looked at blood pressure and heart rate. Their finding suggest that the GABA _A receptor is the most important for mediating the inhibitory response under conscious conditions however , GABA _B receptor were not important for the transduction of inhibitory signals. This suggests that anesthesia might alter the GABA B receptor or even potentiate the effects of GABA binding to GABA _B receptors in anesthetized animals.