The major inhibitory neurotransmitter is GABA .As we already know anesthesia can potentiate the effects of GABA. In this article they looked at the role of GABA on GABA A and GABA B receptors in conscious animals. They used Wistar rats. They only looked at blood pressure and heart rate. Their finding suggest that the GABA A receptor is the most important for mediating the inhibitory response under conscious conditions however , GABA B receptor were not important for the transduction of inhibitory signals. This suggests that anesthesia might alter the GABA B receptor or even potentiate the effects of GABA binding to GABA B receptors in anesthetized animals.
