Local anaesthetics for acute reversible blockade of the sympathetic

Melissa M.J. Farnham, Paul M. Pilowsky

∗Australian School of Advanced Medicine, Level 1, Dow Corning Building, 3 Innovation Rd., Macquarie University, Macquarie, NSW 2109, Australia

Sinoaortic denervation (SAD) is a technique used to determine the role that the baroreceptors play in the control of blood pressure in different pathological states. In this article they discussed an alternative method to the current way of doing a SAD. They should how the use of lignocaine (10 – 30 min) and the bupivacaine (30 – 60 min) can yield result very similar to a complete (fig 2 and 3). The reversible SAD allows for more protocols can be done and also experiments can be done before and after the SAD. This new method allows for both intact and barodenervation to be investigated in the same animal this allows for greater statistical power and will reduce the number animals to be used for experiments. There are some disadvantages to this technique as well. Local anesthetics can have toxic effects on the cardiovascular system. This method will allow for more experiments in animals, along with increasing statistical power but another important reason to try this method that it reduces the amount of animals necessary for experiments thereby making this method more ethical.