Satoru Ito, Kazutoshi Komatsu, Kazuyoshi Tsukamoto and Alan F. Sved
The rvlm is important to tonic and phasic control of blood
pressure. It has been shown in normotensive anesthetized rat that injection of
kyn into RVLM has no effect on BP. However if you block CVLM and give kyn into
RVLM you we see a similar decrease as if you inhibited the RVLM, suggesting
that excitatory amino acids are driving both inhibition and excitation in the
RVLM. The purpose of this study was to
determine the role that excitation and inhibition are playing in hypertension. They used microinjection technique in order to
address their questions. What they found was that in response to kyn into RVLM
the WKYs had no response however the SHR had a decrease in bp of 40mmHG. They then injected muscimol into CVLM and
then kyn into RVLM. They found that after blockade of CVLM in both groups they
saw a decrease in bp when they gave kyn into the rvlm. These data suggests that
CVLM must be provide not only inhibitory input but also some non-excitatory
amino acid input. Also that excitatory amino acids are playing a major role in
driving rvlm activity in hypertensive animals.
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