J. Horiuchi and R.A.L. Dampney
It has been observed that bilateral but not unilateral inactivation of RVLM leads to profound decreases in BP. However, the mechanism that allows for one RVLM under intact baroreceptor conditions to be able to maintain bp is unknown. The current study investigated both unilateral and bilateral inhibition of RVLM on blood pressure and sympathetic output. Method: Following removal of aortic and carotid baroreceptors along with bilateral vagii removal muscimol was injected in the right RVLM and then the left rvlm. MAP, rSNA were recorded along with HR.Results: The response to unilateral blockade of rvlm in SAD rabbits drop MAP to that of spinal levels. It also caused a dramatic fall in rSNA in SAD rabbits when compared to intact rabbits.
Conclusion: Data suggests that the baroreflex is important for maintaining BP and SNA when the activity of RVLM neurons is impaired.
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