McAllen RM, May CN.
This article dates back to more than a decade ago. Microinjection of glutamate in the RVLM of cats have shown to drive the sympathetic outflow differentially based on the area stimulated. Muscle vasoconstrictor activity were driven when the injections were lateral whereas skin vasocontrictor responses were driven when the injections are medial with in the RVLM. In this study the authors were interested in investigating whether seperate RVLM neurons controlling different vasomotor outflows holds true for tissues other than skin and kidney. In addition they further studied the relative strenghts of such specific drives and the location of their cells of origin. Several microinjections of sodium glutamate were given in a grid like pattern covering the RVLM. All the recording were made in cats anesthetized using chloralose. Muscle vasoconstrictor (MVC), visceral vasoconstrictor (VVC), and renal sympathetic nerves (RSN) were recorded. Findings from this study suggest that each of these sympathetic outflow are driven by a seperate population of neurons with in the RVLM.
American Journal of Physiology, 1994
http://ajpregu.physiology.org/content/267/4/R935.full.pdf+html
-Madhan
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